Tafa3^em1Hssh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tafa3^em1Hssh
• Name: TAFA chemokine like family member 3; endonuclease-mediated mutation 1, Hee-Sup Shin
• MGI ID: MGI:6140086
• Synonyms: Sam3^-
• Gene: Tafa3 Location: Chr3:104674721-104686854 bp, - strand Genetic Position: Chr3, 45.84 cM, cytoband F2.2
• Alliance: Tafa3^em1Hssh page

Mutation origin

• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A TALEN-mediated mutation was produced by targeting exon 4, which contains the initiation codon ATG. A 43-bp deletion from this genomic region was confirmed by sequencing, resulting in a frameshift mutation with a premature stop codon. RT-PCR analysis confirmed the absence of mRNA expression in whole brain lysates without the hippocampus as well as in hippocampus only lysates from homozygous mutant mice. (J:257371)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1  Disease Model	Tafa3^em1Hssh/Tafa3^em1Hssh	C57BL/6NTac-Tafa3^em1Hssh
ht2	Tafa3^em1Hssh/Tafa3^+	C57BL/6NTac-Tafa3^em1Hssh

Phenotypes:

Affected Systems	hm1		ht2
show or hide all annotated terms Sex:
behavior/neurological	√	√	√	√
behavior/neurological phenotype	N	N
increased anxiety-related response		√		√
increased grooming behavior	√	√		√
increased locomotor activity			√
increased stereotypic behavior		√		√
abnormal social/conspecific interaction behavior		√
abnormal response to social novelty	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

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disease model

expected model not found

Models:

Human Diseases	hm1
autism spectrum disorder IDs autism spectrum disorder       DOID:0060041 MESH:D000067877 Close	√

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tafa3 Mutation: 6 strains or lines available

References

• Original: J:257371 Kim S, et al., Deficiency of a brain-specific chemokine-like molecule, SAM3, induces cardinal phenotypes of autism spectrum disorders in mice. Sci Rep. 2017 Nov 28;7(1):16503
• All: 1 reference(s)