Pptc7^em2Pagd
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pptc7^em2Pagd
• Name: PTC7 protein phosphatase homolog; endonuclease-mediated mutation 2, David J Pagliarini
• MGI ID: MGI:6143811
• Synonyms: Pptc7E3d1, Pptc7^em2Pag
• Gene: Pptc7 Location: Chr5:122422461-122462344 bp, + strand Genetic Position: Chr5, 62.28 cM
• Alliance: Pptc7^em2Pagd page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Intragenic deletion, Nucleotide substitutions
• Mutation details: CRISPR targeting created a substitution of 3 bases (CGA to TCC) followed by a 1 base pair deletion (A) within exon 3 causing a frameshift. (J:277086)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pptc7 Mutation: 48 strains or lines available

References

• Original: J:277086 Niemi NM, et al., Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis. Nat Commun. 2019 Jul 19;10(1):3197
• All: 1 reference(s)