Asmt^C57BL/6JJcl
Spontaneous Allele Detail

Summary

• Symbol: Asmt^C57BL/6JJcl
• Name: acetylserotonin O-methyltransferase; C57BL/6JJcl
• MGI ID: MGI:6144036
• Synonyms: Asmt^a, Hiomt B6J
• Gene: Asmt Location: ChrX:169106379-169111787 bp, + strand Genetic Position: ChrXY, Syntenic
• Alliance: Asmt^C57BL/6JJcl page

Mutation origin

• Strain of Origin: C57BL/6JJcl

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: Two nonsynonymous SNPs (A>G and C>T) result in amino acid substitutions (p.R78G and p.R242C). Expression of the encoded protein is abolished in this strain. These substitutions are also found in the RIII/Imr, DDD/Sgn and KK/Sgn strains. (J:159317)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Asmt Mutation: 21 strains or lines available

References

• Original: J:159317 Kasahara T, et al., Genetic variation of melatonin productivity in laboratory mice under domestication. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6412-7
• All: 3 reference(s)