Calr^tm1.1Osb
Targeted Allele Detail

Summary

• Symbol: Calr^tm1.1Osb
• Name: calreticulin; targeted mutation 1.1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6144082
• Synonyms: Calr^-, tm1c
• Gene: Calr Location: Chr8:85568717-85573560 bp, - strand Genetic Position: Chr8, 41.21 cM
• Alliance: Calr^tm1.1Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250114
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Exons 4-7 were flanked by loxP sites and subsequently deleted by cre-mediated recombination. (J:250114)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Calr Mutation: 14 strains or lines available

References

• Original: J:250114 Tokuhiro K, et al., Calreticulin is required for development of the cumulus oocyte complex and female fertility. Sci Rep. 2015 Sep 21;5:14254
• All: 3 reference(s)