Nt5c2^tm1.1Aafo
Targeted Allele Detail

Summary

• Symbol: Nt5c2^tm1.1Aafo
• Name: 5'-nucleotidase, cytosolic II; targeted mutation 1.1, Adolfo A Ferrando
• MGI ID: MGI:6147342
• Synonyms: Nt5c2^co-R367Q
• Gene: Nt5c2 Location: Chr19:46873829-47003613 bp, - strand Genetic Position: Chr19, 38.97 cM, cytoband D2
• Alliance: Nt5c2^tm1.1Aafo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257751
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting construct introduced into intron 13 a loxP site, minigene contains exons 14 through 18 and an FRT and loxP site flanked neomycin resistance cassette. The mini gene exon 14 sequence was modified to introduce the nucleotide substitution of AG to CA that results in the amino acid substitution of glutamine for arginine at position 367 (R367Q). (J:257751)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nt5c2 Mutation: 36 strains or lines available

References

• Original: J:257751 Tzoneva G, et al., Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia. Nature. 2018 Jan 25;553(7689):511-514
• All: 1 reference(s)