Ciz1^tm1.1Homy
Targeted Allele Detail

Summary

• Symbol: Ciz1^tm1.1Homy
• Name: CDKN1A interacting zinc finger protein 1; targeted mutation 1.1, Hiroaki Honda
• MGI ID: MGI:6147606
• Synonyms: Ciz1 KO
• Gene: Ciz1 Location: Chr2:32252724-32268311 bp, + strand Genetic Position: Chr2, 22.09 cM, cytoband B
• Alliance: Ciz1^tm1.1Homy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198470
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP was inserted upstream of exon 5 and an FRT flanked neomycin resistance gene cassette with a 3' loxP site was inserted downstream of exon 5. The neo cassette was removed by crossing with FLPe mice (C57BL/6-Tg(CAG-FLPe)36Ito). Exon 5 was deleted through subsequent cre-mediated recombination. (J:198470)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ciz1 Mutation: 51 strains or lines available

References

• Original: J:198470 Nishibe R, et al., CIZ1, a p21Cip1/Waf1-interacting protein, functions as a tumor suppressor in vivo. FEBS Lett. 2013 May 21;587(10):1529-35
• All: 2 reference(s)