Polrmt^tm1.2Arte
Targeted Allele Detail

Summary

• Symbol: Polrmt^tm1.2Arte
• Name: polymerase (RNA) mitochondrial (DNA directed); targeted mutation 1.2, TaconicArtemis
• MGI ID: MGI:6147646
• Gene: Polrmt Location: Chr10:79571957-79582415 bp, - strand Genetic Position: Chr10, 39.72 cM, cytoband C1
• Alliance: Polrmt^tm1.2Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258184
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and F3 flanked puro cassette were inserted upstream of exon 3 and a loxP site was inserted downstream of exon 3 via homologous recombination. Recombinase mediated recombination removed the puro cassette and exon 3. (J:258184)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Polrmt Mutation: 45 strains or lines available

References

• Original: J:258184 Kuhl I, et al., POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA. Sci Adv. 2016 Aug;2(8):e1600963
• All: 2 reference(s)