Dnaaf11^tm1.2Hmd
Targeted Allele Detail

Summary

• Symbol: Dnaaf11^tm1.2Hmd
• Name: dynein axonemal assembly factor 11; targeted mutation 1.2, Hiroshi Hamada
• MGI ID: MGI:6147714
• Synonyms: Lrrc6^-
• Gene: Dnaaf11 Location: Chr15:66251707-66372759 bp, - strand Genetic Position: Chr15, 29.22 cM, cytoband D3
• Alliance: Dnaaf11^tm1.2Hmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258369
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: LoxP-flanked exon 1 was removed by crossing with CAG-Cre mice. Western blot analysis of the trachea using a rabbit anti-Lrrc6 polyclonal antibody confirmed the absence of protein expression in homozygous mutant mice. (J:258369)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnaaf11 Mutation: 26 strains or lines available

References

• Original: J:258369 Inaba Y, et al., Transport of the outer dynein arm complex to cilia requires a cytoplasmic protein Lrrc6. Genes Cells. 2016 Jul;21(7):728-39
• All: 1 reference(s)