Rnaseh2a^tm1Crh
Targeted Allele Detail

Summary

• Symbol: Rnaseh2a^tm1Crh
• Name: ribonuclease H2, large subunit; targeted mutation 1, Robert J Crouch
• MGI ID: MGI:6147721
• Synonyms: Rnaseh2a^G37S
• Gene: Rnaseh2a Location: Chr8:85683239-85694498 bp, - strand Genetic Position: Chr8, 41.38 cM, cytoband C3
• Alliance: Rnaseh2a^tm1Crh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232933
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A serine substitution for glycine 37 (G37S) near the catalytic center on the RNase H2A subunit, a mutation associated with the human Aicardi-Goutieres syndrome, was introduced into this highly conserved residue of the catalytic subunit. A floxed selection cassette is present. (J:232933)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnaseh2a Mutation: 46 strains or lines available

References

• Original: J:232933 Pokatayev V, et al., RNase H2 catalytic core Aicardi-Goutieres syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice. J Exp Med. 2016 Mar 7;213(3):329-36
• All: 1 reference(s)