About   Help   FAQ
Zcchc17tm1Pou
Targeted Allele Detail
Summary
Symbol: Zcchc17tm1Pou
Name: zinc finger, CCHC domain containing 17; targeted mutation 1, Pin Ouyang
MGI ID: MGI:6147733
Synonyms: deltaE2
Gene: Zcchc17  Location: Chr4:130209176-130253736 bp, - strand  Genetic Position: Chr4, 63.43 cM
Alliance: Zcchc17tm1Pou page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:233160
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Modified isoform(s))
Mutation:    Insertion
 
Mutation detailsA PGK-beta-geo (beta-galactosidase-neomycin fusion gene) selection cassette was inserted into exon 2, disrupting the first ATG that gives rise to the long isoform. RT-PCR indicates enhanced mRNA expression of the short isoform (which uses an ATG in exon 4) and disrupted expression of the long isoform. (J:233160)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zcchc17 Mutation:  25 strains or lines available
References
Original:  J:233160 Lin YM, et al., Target disruption of ribosomal protein pNO40 accelerates aging and impairs osteogenic differentiation of mesenchymal stem cells. Biochem Biophys Res Commun. 2016 Jan 22;469(4):903-10
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory