Zcchc17tm3Pou
Targeted Allele Detail
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Symbol: |
Zcchc17tm3Pou |
Name: |
zinc finger, CCHC domain containing 17; targeted mutation 3, Pin Ouyang |
MGI ID: |
MGI:6147770 |
Synonyms: |
deltaE2 + E4 |
Gene: |
Zcchc17 Location: Chr4:130209176-130253736 bp, - strand Genetic Position: Chr4, 63.43 cM
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Alliance: |
Zcchc17tm3Pou page
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Germline Transmission: |
Earliest citation of germline transmission:
J:233160
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129
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Allele Type: |
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Targeted (Modified isoform(s)) |
Mutation: |
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Insertion
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Mutation details: ES cells harboring the Zcchc17tm1Pou
(which contains a PGK-beta-geo (beta-galactosidase-neomycin fusion gene) selection cassette inserted into exon 4) allele were targeted to insert a PGK-hygromycin cassette into exon 2. Both the ATGs in exon 2 (long isoform) and exon 4 (short isoform) are disrupted. RT-PCR indicates enhanced mRNA expression of a miniform spanning exons 1, 6, and 7 (345 bp), which can produce a peptide from an alternative start codon in exon 7.
(J:233160)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Zcchc17 Mutation: |
25 strains or lines available
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Original: |
J:233160 Lin YM, et al., Target disruption of ribosomal protein pNO40 accelerates aging and impairs osteogenic differentiation of mesenchymal stem cells. Biochem Biophys Res Commun. 2016 Jan 22;469(4):903-10 |
All: |
1 reference(s) |
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