Cybb^tm1.1Abk
Targeted Allele Detail

Summary

• Symbol: Cybb^tm1.1Abk
• Name: cytochrome b-245, beta polypeptide; targeted mutation 1.1, Annadora J Bruce-Keller
• MGI ID: MGI:6147802
• Synonyms: Cybb^fl, NOX2-FL
• Gene: Cybb Location: ChrX:9301493-9354005 bp, - strand Genetic Position: ChrX, 4.3 cM
• Alliance: Cybb^tm1.1Abk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:245699
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: This targeting vector obtained from the Wellcome Trust Sanger Institute KOMP (Knockout Mouse Project) is used to insert a L1L2_Bact_P cassette containing FRT-lacZ-loxP-neo-FRT-loxP upstream of exon 5 (at position 9455699 of Chromosome X; Build GRCm38), and a loxP site downstream of exon 5 (at position 9454892). Flp-mediated recombination removed the FRT-flanked lacZ/neo cassette. (J:245699)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cybb Mutation: 45 strains or lines available

References

• Original: J:245699 Pepping JK, et al., Myeloid-specific deletion of NOX2 prevents the metabolic and neurologic consequences of high fat diet. PLoS One. 2017;12(8):e0181500
• All: 4 reference(s)