Slc39a8^tm1.2Mrl
Targeted Allele Detail

Summary

• Symbol: Slc39a8^tm1.2Mrl
• Name: solute carrier family 39 (metal ion transporter), member 8; targeted mutation 1.2, Merck Research Laboratory
• MGI ID: MGI:6147816
• Gene: Slc39a8 Location: Chr3:135531040-135594333 bp, + strand Genetic Position: Chr3, 63.04 cM
• Alliance: Slc39a8^tm1.2Mrl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258360
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and FRT flanked selection cassette were inserted upstream of exon 3 and an F3 site and loxP site were inserted downstream of exon 3 via homologous recombination. Recombinase meditated recombination removed the selection cassette and exon 3. (J:147112, J:258360)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc39a8 Mutation: 43 strains or lines available

References

• Original: J:258360 Lin W, et al., Zinc transporter Slc39a8 is essential for cardiac ventricular compaction. J Clin Invest. 2018 Feb 1;128(2):826-833
• All: 3 reference(s)