Tg(Thy1-SERPINI1*S52R)794Zbz
Transgene Detail

Summary

• Symbol: Tg(Thy1-SERPINI1*S52R)794Zbz
• Name: transgene insertion 794, Universitatsspital Zurich, Biologisches Zentrallab
• MGI ID: MGI:6148212
• Synonyms: S52R-Portland
• Transgene: Tg(Thy1-SERPINI1*S52R)794Zbz Location: unknown
• Alliance: Tg(Thy1-SERPINI1*S52R)794Zbz page

Transgene origin

• Strain of Origin: B6D2F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-SERPINI1*S52R)794Zbz expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SERPINI1 (5274)

  Serpini1

  (MGI:1194506)

• Mutation details: Transgenic mice overexpressing human neuroserpin with the S52R-Portland mutation under the control of the mouse Thy1 promoter were generated by pronuclear injection into fertilized oocytes using an expression cassette derived from the murine Thy1 gene. The S52R-Portland mutation was introduced into the human neuroserpin cDNA using the polymerase chain reaction technique. The transgene was expressed in central nervous system neurons throughout postnatal life. The expression levels for transgenic mice with human Portland neuroserpin is 3.3 times [line Tg(NSS52R)794Zbz] above the endogenous neuroserpin level of wild-type mice. (J:120135)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:120135 Galliciotti G, et al., Accumulation of mutant neuroserpin precedes development of clinical symptoms in familial encephalopathy with neuroserpin inclusion bodies. Am J Pathol. 2007 Apr;170(4):1305-13
• All: 1 reference(s)