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Ccdc141tm1.1Ygi
Targeted Allele Detail
Summary
Symbol: Ccdc141tm1.1Ygi
Name: coiled-coil domain containing 141; targeted mutation 1.1, Shigeru Yanagi
MGI ID: MGI:6148229
Synonyms: CAMDI-KO
Gene: Ccdc141  Location: Chr2:76840246-77000980 bp, - strand  Genetic Position: Chr2, 45.38 cM, cytoband D
Alliance: Ccdc141tm1.1Ygi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:238090
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCre-mediated recombination of loxP sites surrounding exon 4 resulted in a null mutation. An frt-flanked neomycin selection cassette was inserted in intron 3. Western blot analysis of E16 mouse brain lysate demonstrated an absence of the encoded protein in homozygous mice. (J:238090)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccdc141 Mutation:  81 strains or lines available
References
Original:  J:238090 Fukuda T, et al., Rescue of CAMDI deletion-induced delayed radial migration and psychiatric behaviors by HDAC6 inhibitor. EMBO Rep. 2016 Dec;17(12):1785-1798
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory