Miat^tm1Shna
Targeted Allele Detail

Summary

• Symbol: Miat^tm1Shna
• Name: myocardial infarction associated transcript (non-protein coding); targeted mutation 1, Shinichi Nakagawa
• MGI ID: MGI:6148230
• Synonyms: Gomafu^null
• Gene: Miat Location: Chr5:112361094-112376814 bp, - strand Genetic Position: Chr5, 54.59 cM
• Alliance: Miat^tm1Shna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250154
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Mice carrying this allele were generated using TAMERE technology. Embryonic stem (ES) cells bearing insertions of a loxP-PGK-Neo cassette into the first exon (5'delta) or into the polyadenylation signal (3'delta) were generated. Chimeric mice were generated with the recombinant ES clones and were subsequently mated with transgenic mice (B6;D2-Tg(Sycp1-cre)4 Min/J) that express the Cre recombinase under the control of Sycp1 to generate double heterozygous mice. These mice were inter-crossed to generate trans-heterozygous (5'delta/3'delta) mice with the Sycp1-Cre transgene. Male mice produced sperm that had the alleles completely deleted and were studied further. (J:250154)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Miat Mutation: 0 strains or lines available

References

• Original: J:250154 Ip JY, et al., Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine. Sci Rep. 2016 Jun 2;6:27204
• All: 4 reference(s)