Usp15^L749R
Chemically induced Allele Detail

Summary

• Symbol: Usp15^L749R
• Name: ubiquitin specific peptidase 15; L749R
• MGI ID: MGI:6149704
• Gene: Usp15 Location: Chr10:122940911-123032900 bp, - strand Genetic Position: Chr10, 72.31 cM, cytoband D3
• Alliance: Usp15^L749R page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to G point mutation in exon 17 that produces an amino acid substitution of leucine with arginine at position 749 (L749R). (J:259382)
• Inheritance: Other (see notes)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Usp15^L749R/Usp15^L749R	involves: 129S1/SvImJ * C57BL/6J
ht2	Usp15^L749R/Usp15^+	involves: 129S1/SvImJ * C57BL/6J
ht3	Usp15^L749R/Usp15^tm1Pgrs	involves: 129S1/SvImJ * C57BL/6J
cx4	Trim25^tm1Mura/Trim25^+ Usp15^L749R/Usp15^+	involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

Phenotypes:

Affected Systems	hm1	ht2	ht3	cx4
show or hide all annotated terms
hematopoietic system	√
abnormal T-helper 1 physiology	√
immune system	√	√	√	√
immune system phenotype	N
abnormal T-helper 1 physiology	√
decreased susceptibility to experimental autoimmune encephalomyelitis	√	√	√	√
decreased susceptibility to bacterial infection	√
decreased susceptibility to bacterial infection induced morbidity/mortality	√
decreased susceptibility to parasitic infection	√
decreased susceptibility to parasitic infection induced morbidity/mortality	√	√	√	√
mortality/aging	√	√	√	√
decreased susceptibility to bacterial infection induced morbidity/mortality	√
decreased susceptibility to parasitic infection induced morbidity/mortality	√	√	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp15 Mutation: 60 strains or lines available

Notes

This allele is inherited in an ncompletely recessive mode.

References

• Original: J:259382 Torre S, et al., USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation. Nat Immunol. 2017 Jan;18(1):54-63
• All: 1 reference(s)