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Daam2tm1Tpy
Targeted Allele Detail
Summary
Symbol: Daam2tm1Tpy
Name: dishevelled associated activator of morphogenesis 2; targeted mutation 1, Terry Yamaguchi
MGI ID: MGI:6149781
Synonyms: Daam2lacZ
Gene: Daam2  Location: Chr17:49763050-49871371 bp, - strand  Genetic Position: Chr17, 25.5 cM
Alliance: Daam2tm1Tpy page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:228507
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsAn IRES-lacZ cassette and a loxP site flanked PGK-neo cassette were inserted into a PstI site in exon 10, creatuing a reporter-knockout allele. (J:228507)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
involves: 129S1/Sv * 129S7/SvEvBrd
 
Phenotypes:
Affected Systems
show or hide all annotated terms
 
cardiovascular system
cardiovascular system phenotype
N
abnormal myocardial fiber morphology
abnormal intercalated disk morphology
abnormal myocardial trabeculae morphology
heart hypoplasia
abnormal heart left ventricle morphology
abnormal heart right ventricle morphology
decreased left ventricle systolic pressure
decreased right ventricle systolic pressure
abnormal myocardial fiber physiology
muscle
abnormal myocardial fiber morphology
abnormal intercalated disk morphology
abnormal myocardial trabeculae morphology
abnormal A band morphology
abnormal H zone morphology
absent M line
abnormal I band morphology
absent Z line
diffuse Z line
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Daam2 Mutation:  50 strains or lines available
References
Original:  J:228507 Ajima R, et al., DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly. Dev Biol. 2015 Dec 1;408(1):126-39
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory