Daam2tm1Tpy
Targeted Allele Detail
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Symbol: |
Daam2tm1Tpy |
Name: |
dishevelled associated activator of morphogenesis 2; targeted mutation 1, Terry Yamaguchi |
MGI ID: |
MGI:6149781 |
Synonyms: |
Daam2lacZ |
Gene: |
Daam2 Location: Chr17:49763050-49871371 bp, - strand Genetic Position: Chr17, 25.5 cM
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Alliance: |
Daam2tm1Tpy page
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutation: |
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Insertion
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Mutation details: An IRES-lacZ cassette and a loxP site flanked PGK-neo cassette were inserted into a PstI site in exon 10, creatuing a reporter-knockout allele.
(J:228507)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: 129S1/Sv * 129S7/SvEvBrd | |
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Phenotypes: |
Affected Systems |
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cardiovascular system
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cardiovascular system phenotype
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N
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abnormal myocardial fiber morphology
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√
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abnormal intercalated disk morphology
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√
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abnormal myocardial trabeculae morphology
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√
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heart hypoplasia
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√
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abnormal heart left ventricle morphology
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abnormal heart right ventricle morphology
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decreased left ventricle systolic pressure
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decreased right ventricle systolic pressure
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abnormal myocardial fiber physiology
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muscle
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abnormal myocardial fiber morphology
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√
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abnormal intercalated disk morphology
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√
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abnormal myocardial trabeculae morphology
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√
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abnormal A band morphology
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abnormal H zone morphology
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√
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absent M line
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√
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abnormal I band morphology
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√
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absent Z line
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√
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diffuse Z line
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Daam2 Mutation: |
50 strains or lines available
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Original: |
J:228507 Ajima R, et al., DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly. Dev Biol. 2015 Dec 1;408(1):126-39 |
All: |
2 reference(s) |
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