Zfp106^em1Blk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zfp106^em1Blk
• Name: zinc finger protein 106; endonuclease-mediated mutation 1, Brian L Black
• MGI ID: MGI:6149784
• Synonyms: Zfp106^DELTA
• Gene: Zfp106 Location: Chr2:120337301-120394324 bp, - strand Genetic Position: Chr2, 60.37 cM, cytoband F1
• Alliance: Zfp106^em1Blk page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 1 was targeted with two sgRNAs using the CRISPR/Cas9 system, resulting in a frameshift mutation that creates a premature stop codon. (J:241305)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp106 Mutation: 116 strains or lines available

References

• Original: J:241305 Celona B, et al., Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106. Elife. 2017 Jan 10;6:e19032
• All: 1 reference(s)