Ppp2r2a^igt10
Chemically induced Allele Detail

Summary

• Symbol: Ppp2r2a^igt10
• Name: protein phosphatase 2, regulatory subunit B, alpha; impaired glucose tolerance 10
• MGI ID: MGI:6149954
• Gene: Ppp2r2a Location: Chr14:67251505-67309893 bp, - strand Genetic Position: Chr14, 34.6 cM, cytoband D1
• Alliance: Ppp2r2a^igt10 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to G point mutation in intron 3 that generates a new acceptor splice site. Reduced protein expression is detected in liver, skeletal muscle and white adipose tissue. (J:246319)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp2r2a Mutation: 54 strains or lines available

References

• Original: J:246319 Goldsworthy M, et al., Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse Model of Type 2 Diabetes. Diabetes. 2016 May;65(5):1434-46
• All: 1 reference(s)