Acap2^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Acap2^em1(IMPC)J
• Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 2; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6149965
• Gene: Acap2 Location: Chr16:30911230-31020063 bp, - strand Genetic Position: Chr16, 21.34 cM, cytoband B2
• Alliance: Acap2^em1(IMPC)J page
• IMPC: Acap2 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences AGAGGTTCTGAAGTGAGGCG, GCTAACCGCTCATCACGGAA, AGTGAGAACACAGATACAAA and TTATTGTCACGTTTACATAA, which resulted in a 239 bp deletion beginning at Chromosome 16 position 31,160,270 bp and ending after 31,160,508 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000128130 (exon 2) and 181 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 17 and early truncation 2 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Acap2 Mutation: 56 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)