Gpr158^tm1.1Kry
Targeted Allele Detail

Summary

• Symbol: Gpr158^tm1.1Kry
• Name: G protein-coupled receptor 158; targeted mutation 1.1, Gerard Karsenty
• MGI ID: MGI:6150061
• Synonyms: Gpr158^f
• Gene: Gpr158 Location: Chr2:21372378-21835355 bp, + strand Genetic Position: Chr2, 14.92 cM
• Alliance: Gpr158^tm1.1Kry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:246056
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and FRT-flanked neomycin cassette followed by a second loxP site were inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette, leaving exon 2 floxed. (J:246056)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr158 Mutation: 74 strains or lines available

References

• Original: J:246056 Khrimian L, et al., Gpr158 mediates osteocalcin's regulation of cognition. J Exp Med. 2017 Oct 02;214(10):2859-2873
• All: 3 reference(s)