Kifbp^em2Hmy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kifbp^em2Hmy
• Name: kinesin family binding protein; endonuclease-mediated mutation 2, Heather Young
• MGI ID: MGI:6150323
• Synonyms: line 2
• Gene: Kifbp Location: Chr10:62394249-62414846 bp, - strand Genetic Position: Chr10, 32.43 cM, cytoband B4
• Alliance: Kifbp^em2Hmy page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A deletion of exon 1 was generated by CRISPR/Cas9 mutagenesis. Western blotting showed an absence of encoded protein in newborn homozygous mice. (J:253679)

Disease models

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kifbp Mutation: 36 strains or lines available

References

• Original: J:253679 Hirst CS, et al., Kif1bp loss in mice leads to defects in the peripheral and central nervous system and perinatal death. Sci Rep. 2017 Nov 30;7(1):16676
• All: 1 reference(s)