Shmt2^em1Jiha
Endonuclease-mediated Allele Detail

Summary

• Symbol: Shmt2^em1Jiha
• Name: serine hydroxymethyltransferase 2 (mitochondrial); endonuclease-mediated mutation 1, Jun-Ichi Hayashi
• MGI ID: MGI:6150909
• Synonyms: Shmt2 m
• Gene: Shmt2 Location: Chr10:127352992-127358313 bp, - strand Genetic Position: Chr10, 74.51 cM
• Alliance: Shmt2^em1Jiha page

Mutation origin

• Strain of Origin: C57BL/6JJcl

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Intragenic deletion
• CRISPR mutagenesis induced an insertion of a single T in the gene, resulting in a frame shift. (J:259713)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shmt2 Mutation: 33 strains or lines available

References

• Original: J:259713 Tani H, et al., Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal. Sci Rep. 2018 Jan 11;8(1):425
• All: 2 reference(s)