Gcat^em1Jiha
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gcat^em1Jiha
• Name: glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase); endonuclease-mediated mutation 1, Jun-Ichi Hayashi
• MGI ID: MGI:6150910
• Synonyms: Gcat m
• Gene: Gcat Location: Chr15:78915074-78926731 bp, + strand Genetic Position: Chr15, 37.7 cM
• Alliance: Gcat^em1Jiha page

Mutation origin

• Strain of Origin: C57BL/6JJcl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR mutagenesis induced a 7 bp insertion and a 39 bp deletion in the gene. The encoded protein was not detectable in livers of 5-month-old homozygous mice. (J:259713)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gcat Mutation: 21 strains or lines available

References

• Original: J:259713 Tani H, et al., Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal. Sci Rep. 2018 Jan 11;8(1):425
• All: 1 reference(s)