Mgme1^tm1.2Lrsn
Targeted Allele Detail

Summary

• Symbol: Mgme1^tm1.2Lrsn
• Name: mitochondrial genome maintenance exonuclease 1; targeted mutation 1.2, Nils-Goran Larsson
• MGI ID: MGI:6150912
• Gene: Mgme1 Location: Chr2:144112824-144123147 bp, + strand Genetic Position: Chr2, 70.98 cM, cytoband H1
• Alliance: Mgme1^tm1.2Lrsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259702
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was flanked by loxP sites. The puromycin resistance cassette was removed by mating of heterozygous mice with transgenic mice ubiquitously expressing Flp-recombinase. Cre-mediated recombination removed exon 3. (J:259702)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mgme1 Mutation: 65 strains or lines available

References

• Original: J:259702 Matic S, et al., Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria. Nat Commun. 2018 Mar 23;9(1):1202
• All: 3 reference(s)