B4galt6^tm1Kfk
Targeted Allele Detail

Summary

• Symbol: B4galt6^tm1Kfk
• Name: UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6; targeted mutation 1, Koichi Furukawa
• MGI ID: MGI:6151125
• Gene: B4galt6 Location: Chr18:20817656-20879461 bp, - strand Genetic Position: Chr18, 11.48 cM
• Alliance: B4galt6^tm1Kfk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260410
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 3' region of exon 1 including the ATG site and the 5' region of intron 1 were replaced with a neomycin resistance cassette. No detectable transcript is expressed from this allele in brain of 11 week old homozygous mice. (J:260410)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any B4galt6 Mutation: 48 strains or lines available

References

• Original: J:260410 Tokuda N, et al., beta4GalT6 is involved in the synthesis of lactosylceramide with less intensity than beta4GalT5. Glycobiology. 2013 Oct;23(10):1175-83
• All: 2 reference(s)