Cd53^tm1.1Nmg
Targeted Allele Detail

Summary

• Symbol: Cd53^tm1.1Nmg
• Name: CD53 antigen; targeted mutation 1.1, University of Nijmegen
• MGI ID: MGI:6151126
• Synonyms: CD53 floxed
• Gene: Cd53 Location: Chr3:106667237-106697465 bp, - strand Genetic Position: Chr3, 46.53 cM
• Alliance: Cd53^tm1.1Nmg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260065
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and an inverted neomycin resistance cassette were inserted downstream of exon 1. An additional loxP site was inserted upstream of exon 6. Cre-mediated recombination remove exons 2 through 5. (J:260065)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd53 Mutation: 21 strains or lines available

References

• Original: J:260065 Zuidscherwoude M, et al., Tetraspanin microdomains control localized protein kinase C signaling in B cells. Sci Signal. 2017 May 9;10(478)
• All: 4 reference(s)