Cd53^tm1.1Nmg
Targeted Allele Detail

Summary

• Symbol: Cd53^tm1.1Nmg
• Name: CD53 antigen; targeted mutation 1.1, University of Nijmegen
• MGI ID: MGI:6151126
• Synonyms: CD53 floxed
• Gene: Cd53 Location: Chr3:106667237-106697465 bp, - strand Genetic Position: Chr3, 46.53 cM
• Alliance: Cd53^tm1.1Nmg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260065
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and an inverted neomycin resistance cassette were inserted downstream of exon 1. An additional loxP site was inserted upstream of exon 6. Cre-mediated recombination remove exons 2 through 5. (J:260065)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Cd53^tm1.1Nmg/Cd53^tm1.1Nmg	involves: C57BL/6J

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
hematopoietic system	√
abnormal B cell physiology	√
immune system	√
abnormal B cell physiology	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd53 Mutation: 21 strains or lines available

References

• Original: J:260065 Zuidscherwoude M, et al., Tetraspanin microdomains control localized protein kinase C signaling in B cells. Sci Signal. 2017 May 9;10(478)
• All: 4 reference(s)