Cnot3^tm1.1Kjkb
Targeted Allele Detail

Summary

• Symbol: Cnot3^tm1.1Kjkb
• Name: CCR4-NOT transcription complex, subunit 3; targeted mutation 1.1, Keiji Kuba
• MGI ID: MGI:6151142
• Synonyms: Cnot3^f
• Gene: Cnot3 Location: Chr7:3648267-3664108 bp, + strand Genetic Position: Chr7, 2.1 cM
• Alliance: Cnot3^tm1.1Kjkb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260012
• Parent Cell Line: A9 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT- and loxP-site was flanked inverted neomycin resistance cassette. Flp-mediated recombination removed the selection cassette and left exons 2 and 3 floxed. (J:260012)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnot3 Mutation: 35 strains or lines available

References

• Original: J:260012 Yamaguchi T, et al., The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Sci Signal. 2018 Feb 6;11(516)
• All: 3 reference(s)