Sp9^tm1.1Zyan
Targeted Allele Detail

Summary

• Symbol: Sp9^tm1.1Zyan
• Name: trans-acting transcription factor 9; targeted mutation 1.1, Zhengang Yang
• MGI ID: MGI:6152404
• Synonyms: Sp9^LacZ
• Gene: Sp9 Location: Chr2:73094809-73106115 bp, + strand Genetic Position: Chr2, 43.52 cM
• Alliance: Sp9^tm1.1Zyan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238868
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A targeting vector was designed to insert a FRT site followed by an splice acceptor (SA) fused to the internal ribosomal entry site (IRES) and a lacZ gene, a loxP site, a neomycin resistance gene cassette, a second FRT site and a second loxP site (FRT-lacZ-loxP-Neo-FRT-loxP) intron 1 and a third loxP site immediately downstream of the exon2. Cre-mediated recombination removed the neo cassette and exon 2 from Sp9^tm1Zyan leaving lacZ casset under control of endogneous promoter of Sp9. This is a null allele. (J:238868)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sp9 Mutation: 21 strains or lines available

References

• Original: J:238868 Zhang Q, et al., The Zinc Finger Transcription Factor Sp9 Is Required for the Development of Striatopallidal Projection Neurons. Cell Rep. 2016 Aug 02;16(5):1431-44
• All: 6 reference(s)