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Sp9tm1.2Zyan
Targeted Allele Detail
Summary
Symbol: Sp9tm1.2Zyan
Name: trans-acting transcription factor 9; targeted mutation 1.2, Zhengang Yang
MGI ID: MGI:6152405
Synonyms: Sp9flox
Gene: Sp9  Location: Chr2:73094809-73106115 bp, + strand  Genetic Position: Chr2, 43.52 cM
Alliance: Sp9tm1.2Zyan page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:238868
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a FRT site followed by an splice acceptor (SA) fused to the internal ribosomal entry site (IRES) and a lacZ gene, a loxP site, a neomycin resistance gene cassette, a second FRT site and a second loxP site (FRT-lacZ-loxP-Neo-FRT-loxP) intron 1 and a third loxP site immediately downstream of the exon2. Flpe-mediated recombination removed reporter and neo cassette from Sp9tm1Zyan leaving a single FRT site in intoron 1 and loxP flanked exon 2. This allele is a conditional-ready allele. (J:238868)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sp9 Mutation:  21 strains or lines available
References
Original:  J:238868 Zhang Q, et al., The Zinc Finger Transcription Factor Sp9 Is Required for the Development of Striatopallidal Projection Neurons. Cell Rep. 2016 Aug 02;16(5):1431-44
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory