Kcnh8^em1(IMPC)Mbp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kcnh8^em1(IMPC)Mbp
• Name: potassium voltage-gated channel, subfamily H (eag-related), member 8; endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• MGI ID: MGI:6152504
• Gene: Kcnh8 Location: Chr17:52909737-53286222 bp, + strand Genetic Position: Chr17, 27.37 cM
• Alliance: Kcnh8^em1(IMPC)Mbp page
• IMPC: Kcnh8 gene page

Mutation origin

• Strain of Origin: C57BL/6NCrl
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele from IMPC was generated at UC Davis by injecting CAS9 Protein and 2 guide sequences CCTACGCAAAGCCAAAGATGAGT, CCCTAGGTGACAAGATTTTCACT, which resulted in a Exon Deletion. (J:237616)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Kcnh8^em1(IMPC)Mbp/Kcnh8^em1(IMPC)Mbp	C57BL/6N-Kcnh8^em1(IMPC)Mbp/Ucd

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms Sex:
Source:	IMPC - UCD	IMPC - UCD
cardiovascular system		√
enlarged heart		√
endocrine/exocrine glands	√	√
abnormal ovary morphology	√
abnormal testis morphology		√
enlarged testis		√
growth/size/body	√	√
enlarged heart		√
enlarged spleen	√
hematopoietic system	√
abnormal spleen morphology	√
enlarged spleen	√
immune system	√
abnormal spleen morphology	√
enlarged spleen	√
enlarged lymph nodes	√
integument	√
abnormal skin morphology	√
liver/biliary system		√
abnormal liver morphology		√
reproductive system	√	√
abnormal ovary morphology	√
abnormal testis morphology		√
enlarged testis		√
hydrometra	√
vision/eye	√
abnormal eye morphology	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcnh8 Mutation: 91 strains or lines available

References

• Original: J:237616 MGI and IMPC, MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). MGI Direct Data Submission. 2017-8
• All: 3 reference(s)