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Lao1tm1Oka
Targeted Allele Detail
Summary
Symbol: Lao1tm1Oka
Name: L-amino acid oxidase 1; targeted mutation 1, Masaru Okabe
MGI ID: MGI:6152753
Synonyms: LAO-, LAO-KO
Gene: Lao1  Location: Chr4:118819164-118826107 bp, + strand  Genetic Position: Chr4, 55.24 cM
Alliance: Lao1tm1Oka page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:260668
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced exons 1-3, including the start codon. Northern blot analysis showed that no detectable transcript is expressed from this allele in mammary glands of homozygous female mice. No encoded protein is present in milk derived from homozyous female mice. (J:260668)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lao1 Mutation:  25 strains or lines available
References
Original:  J:260668 Nagaoka K, et al., L-amino acid oxidase plays a crucial role in host defense in the mammary glands. FASEB J. 2009 Aug;23(8):2514-20
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory