Lao1^tm1Oka
Targeted Allele Detail

Summary

• Symbol: Lao1^tm1Oka
• Name: L-amino acid oxidase 1; targeted mutation 1, Masaru Okabe
• MGI ID: MGI:6152753
• Synonyms: LAO^-, LAO-KO
• Gene: Lao1 Location: Chr4:118819164-118826107 bp, + strand Genetic Position: Chr4, 55.24 cM
• Alliance: Lao1^tm1Oka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260668
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exons 1-3, including the start codon. Northern blot analysis showed that no detectable transcript is expressed from this allele in mammary glands of homozygous female mice. No encoded protein is present in milk derived from homozyous female mice. (J:260668)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lao1 Mutation: 25 strains or lines available

References

• Original: J:260668 Nagaoka K, et al., L-amino acid oxidase plays a crucial role in host defense in the mammary glands. FASEB J. 2009 Aug;23(8):2514-20
• All: 4 reference(s)