Tinagl1^tm1.1Maru
Targeted Allele Detail

Summary

• Symbol: Tinagl1^tm1.1Maru
• Name: tubulointerstitial nephritis antigen-like 1; targeted mutation 1.1, Hiromichi Matsumoto
• MGI ID: MGI:6153214
• Gene: Tinagl1 Location: Chr4:130059393-130068915 bp, - strand Genetic Position: Chr4, 63.43 cM, cytoband D3
• Alliance: Tinagl1^tm1.1Maru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260681
• Parent Cell Line: EGR-G01 (ES Cell)
• Strain of Origin: (129S2/SvPas x C57BL/6NSlc)F1-Tg(CAG-EGFP,Acr-EGFP)2Osb

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and a FRT-flanked neomycin resistance gene were inserted upstream of exon 3 and a second loxP site was inserted downstream of exon 3. Cre-mediated recombination removed both the neomycin gene and exon 3. Immunohistochemical analysis confirmed absence of protein in the artery and kidney glomerulus. (J:260681)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tinagl1 Mutation: 28 strains or lines available

References

• Original: J:260681 Takahashi A, et al., Impaired female fertility in tubulointerstitial antigen-like 1-deficient mice. J Reprod Dev. 2016;62(1):43-9
• All: 3 reference(s)