Filip1^tm1Msat
Targeted Allele Detail

Summary

• Symbol: Filip1^tm1Msat
• Name: filamin A interacting protein 1; targeted mutation 1, Makoto Sato
• MGI ID: MGI:6153511
• Synonyms: FILIP^-
• Gene: Filip1 Location: Chr9:79712376-79920133 bp, - strand Genetic Position: Chr9, 43.83 cM, cytoband E2
• Alliance: Filip1^tm1Msat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260692
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A Beta-galactosidase gene was inserted in frame following the first 162 bp of exon 5, and the remainder of exon 5 and a portion of intron 5 were replaced with the PGK-neomyin selection cassette. Western blot analysis confirmed absence of protein in homozygotes. (J:260692)

Expression

In Mice Carrying this Mutation:	56 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Filip1 Mutation: 61 strains or lines available

References

• Original: J:260692 Yagi H, et al., Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation. Sci Rep. 2014 Sep 15;4:6353
• All: 3 reference(s)