Fat1^tm1.1Nsib
Targeted Allele Detail

Summary

• Symbol: Fat1^tm1.1Nsib
• Name: FAT atypical cadherin 1; targeted mutation 1.1, Nicholas Sibinga
• MGI ID: MGI:6153609
• Synonyms: Fat1^fl, Fat1^loxP, Fat1^tm1.1Atuf
• Gene: Fat1 Location: Chr8:45388484-45505294 bp, + strand Genetic Position: Chr8, 24.81 cM
• Alliance: Fat1^tm1.1Nsib page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234732
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites and a FRT-flanked neomycin selection cassette was inserted. Flp-mediated recombination removed the selection cassette, leaving exon 2 floxed. (J:234732)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fat1 Mutation: 208 strains or lines available

References

• Original: J:234732 Gee HY, et al., FAT1 mutations cause a glomerulotubular nephropathy. Nat Commun. 2016;7:10822
• All: 2 reference(s)