Slc22a12^tm1Oka
Targeted Allele Detail

Summary

• Symbol: Slc22a12^tm1Oka
• Name: solute carrier family 22 (organic anion/cation transporter), member 12; targeted mutation 1, Masaru Okabe
• MGI ID: MGI:6153680
• Synonyms: Urat1^-
• Gene: Slc22a12 Location: Chr19:6585875-6593062 bp, - strand Genetic Position: Chr19, 5.05 cM, cytoband A
• Alliance: Slc22a12^tm1Oka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260689
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.4 kb gene segment including exons 14 was replaced with a neomycin selection cassette. Northern blot analysis on total kidney RNA showed that no detectable transcript was present in homozygous mutant mice. Western blot analysis on kidney membrane fractions showed that no detectable encoded protein is present in homozygous mutant mice. (J:260689)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc22a12 Mutation: 26 strains or lines available

References

• Original: J:260689 Hosoyamada M, et al., Establishment and analysis of SLC22A12 (URAT1) knockout mouse. Nucleosides Nucleotides Nucleic Acids. 2010 Jun;29(4-6):314-20
• All: 3 reference(s)