Trim8^{em1(IMPC)Wtsi}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trim8^{em1(IMPC)Wtsi}
• Name: tripartite motif-containing 8; endonuclease-mediated mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:6153692
• Gene: Trim8 Location: Chr19:46490087-46504894 bp, + strand Genetic Position: Chr19, 38.92 cM, cytoband D1
• Alliance: Trim8^{em1(IMPC)Wtsi} page
• IMPC: Trim8 gene page

Mutation origin

• Strain of Origin: C57BL/6N
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• This allele from IMPC was generated at Welcome Trust Sanger Institute. (J:237616)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Trim8^em1(IMPC)Wtsi/Trim8^em1(IMPC)Wtsi	C57BL/6N-Trim8^em1(IMPC)Wtsi/Wtsi

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms Sex:
Source:	IMPC - WTSI	IMPC - WTSI
growth/size/body	√	√
increased body length	√	√
hematopoietic system	√
increased mean corpuscular hemoglobin	√
homeostasis/metabolism	√	√
decreased circulating cholesterol level	√	√
decreased circulating HDL cholesterol level	√
decreased circulating serum albumin level	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Trim8 Mutation: 28 strains or lines available

References

• Original: J:237616 MGI and IMPC, MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). MGI Direct Data Submission. 2017-8
• All: 3 reference(s)