Psmb10^Tub6
Chemically induced Allele Detail

Summary

• Symbol: Psmb10^Tub6
• Name: proteasome (prosome, macropain) subunit, beta type 10; Tub6
• MGI ID: MGI:6154286
• Synonyms: MECL-1^G170W, TUB006
• Gene: Psmb10 Location: Chr8:106662360-106665024 bp, - strand Genetic Position: Chr8, 53.06 cM
• Alliance: Psmb10^Tub6 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU induced a point mutation of C to A in exon 7 that results in the non-synonymous amino acid substitution of tryptophan for glycine at position 209 (Gly209Trp; location in the mature protein without propeptide, starting with t1, aligned to thermoplasma: Gly170Trp). (J:261081)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Psmb10 Mutation: 18 strains or lines available

References

• Original: J:261081 Treise I, et al., Defective immuno- and thymoproteasome assembly causes severe immunodeficiency. Sci Rep. 2018 Apr 13;8(1):5975
• All: 1 reference(s)