Oas2^M1Apb
Chemically induced Allele Detail

Summary

• Symbol: Oas2^M1Apb
• Name: 2'-5' oligoadenylate synthetase 2; mutation 1, Australian Phenomics Facility
• MGI ID: MGI:6154625
• Synonyms: Oas2 (I405N)
• Gene: Oas2 Location: Chr5:120868398-120887918 bp, - strand Genetic Position: Chr5, 60.64 cM, cytoband F
• Alliance: Oas2^M1Apb page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: An ENU-induced point mutation in conserved codon 405 alters the encoded amino acid from isoleucine to asparagine (p.Ile405Asn or p.I405N). This substitution is in a conserved region of the catalytic domain of the encoded peptide. (J:248944)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oas2 Mutation: 46 strains or lines available

References

• Original: J:248944 Oakes SR, et al., A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation. PLoS Genet. 2017 Nov;13(11):e1007072
• All: 1 reference(s)