Dnmt3c^em4Sky
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dnmt3c^em4Sky
• Name: DNA methyltransferase 3C; endonuclease-mediated mutation 4, Scott Keeney
• MGI ID: MGI:6156106
• Synonyms: Dnmt3c^em4
• Gene: Dnmt3c Location: Chr2:153538572-153571827 bp, + strand Genetic Position: Chr2, Syntenic
• Alliance: Dnmt3c^em4Sky page

Mutation origin

• Strain of Origin: (CBA x C57BL/6)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 4 induced a framshift mutation due to a 34 bp deletion. (J:244795)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnmt3c Mutation: 13 strains or lines available

References

• Original: J:244795 Jain D, et al., rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline. PLoS Genet. 2017 Aug;13(8):e1006964
• All: 1 reference(s)