Shank2^{em2(IMPC)Rbrc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Shank2^{em2(IMPC)Rbrc}
• Name: SH3 and multiple ankyrin repeat domains 2; endonuclease-mediated mutation 2, RIKEN BioResource Center
• MGI ID: MGI:6156159
• Gene: Shank2 Location: Chr7:143555665-143978231 bp, + strand Genetic Position: Chr7, 88.45 cM
• Alliance: Shank2^{em2(IMPC)Rbrc} page
• IMPC: Shank2 gene page

Mutation origin

• Strain of Origin: C57BL/6N
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele from IMPC was generated at RIKEN BioResource Center by injecting CAS9 RNA and 2 guide sequences ACTGGCAGGCGGTTTCGGTATGG, CGAGCATACCCTACCCACCGAGG, which resulted in a Exon Deletion. (J:237616)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Shank2^em2(IMPC)Rbrc/Shank2^em2(IMPC)Rbrc	C57BL/6NJcl-Shank2^em2(IMPC)Rbrc/Rbrc

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms Sex:
Source:	IMPC - RBRC	IMPC - RBRC
behavior/neurological	√	√
abnormal behavior	√	√
increased thigmotaxis	√	√
limb grasping	√	√
abnormal locomotor behavior	√	√
hyperactivity	√	√
hematopoietic system		√
decreased erythrocyte cell number		√
skeleton	√	√
increased bone mineral content	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shank2 Mutation: 92 strains or lines available

References

• Original: J:237616 MGI and IMPC, MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). MGI Direct Data Submission. 2017-8
• All: 3 reference(s)