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Gars1em1(IMPC)Tcp
Endonuclease-mediated Allele Detail
Summary
Symbol: Gars1em1(IMPC)Tcp
Name: glycyl-tRNA synthetase 1; endonuclease-mediated mutation 1, The Centre for Phenogenomics
MGI ID: MGI:6156586
Gene: Gars1  Location: Chr6:55014992-55056485 bp, + strand  Genetic Position: Chr6, 27.29 cM
Alliance: Gars1em1(IMPC)Tcp page
IMPC: Gars1 gene page
Mutation
origin
Strain of Origin:  C57BL/6NCrl
Project Collection: IMPC
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele from project TCPR0862 was generated at The Centre for Phenogenomics by electroporating Cas9 ribonucleoprotein complexes with single guide RNAs having spacer sequences of GCTCCCTCTACTCACTGAAA and GTAACGCTCTTTGGCGCAGA targeting the 5' side and GGTTAGCTATTAACTTGTAA and ATATACCTGCTGCTCACAGG targeting the 3' side leading to a 409-bp deletion from Chr6:55050182 to 55050590 (GRCm38). (J:237616)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Phenotypes:
Affected Systems
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Source:
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IMPC - TCP
IMPC - TCP
IMPC - TCP
behavior/neurological
decreased exploration in new environment
cardiovascular system
enlarged heart
digestive/alimentary system
abnormal stomach morphology
endocrine/exocrine glands
abnormal seminal vesicle morphology
growth/size/body
enlarged heart
enlarged urinary bladder
hematopoietic system
small spleen
homeostasis/metabolism
increased circulating triglyceride level
immune system
small spleen
integument
abnormal skin morphology
mortality/aging
prenatal lethality prior to heart atrial septation
embryonic lethality prior to organogenesis
preweaning lethality, complete penetrance
renal/urinary system
enlarged urinary bladder
reproductive system
abnormal seminal vesicle morphology
skeleton
abnormal sternum morphology
vision/eye
abnormal eye morphology
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gars1 Mutation:  42 strains or lines available
References
Original:  J:237616 MGI and IMPC, MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). MGI Direct Data Submission. 2017-8;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory