Eprs1^tm1.1Xen
Targeted Allele Detail

Summary

• Symbol: Eprs1^tm1.1Xen
• Name: glutamyl-prolyl-tRNA synthetase 1; targeted mutation 1.1, Taconic Biosciences
• MGI ID: MGI:6156792
• Synonyms: Eprs^A, Eprs^S999A
• Gene: Eprs1 Location: Chr1:185095241-185160557 bp, + strand Genetic Position: Chr1, 89.5 cM, cytoband H4-H6
• Alliance: Eprs1^tm1.1Xen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244749
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: A point mutation (TCA to GCA) in exon 20 results in the amino acid substitution of alanine for serine at position 999 (S999A). Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:244749)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eprs1 Mutation: 82 strains or lines available

References

• Original: J:244749 Arif A, et al., EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice. Nature. 2017 Feb 16;542(7641):357-361
• All: 1 reference(s)