Marveld2^tm1Sats
Targeted Allele Detail

Summary

• Symbol: Marveld2^tm1Sats
• Name: MARVEL (membrane-associating) domain containing 2; targeted mutation 1, Sachiko Tsukita
• MGI ID: MGI:6156852
• Synonyms: Tric^-
• Gene: Marveld2 Location: Chr13:100732465-100753479 bp, - strand Genetic Position: Chr13, 53.23 cM
• Alliance: Marveld2^tm1Sats page

Progressive degeneration of hair cells in the organ of Corti of Marveld2^tm1Sats/Marveld2^tm1Sats mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261357
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP-flanked PGK-Neo cassette replaced exon 2. Western blot analysis confirmed the absence of protein in homozygotes. (J:261357)

Generation of the Marveld2^tm1Sats allele

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Marveld2 Mutation: 30 strains or lines available

References

• Original: J:261357 Kamitani T, et al., Deletion of Tricellulin Causes Progressive Hearing Loss Associated with Degeneration of Cochlear Hair Cells. Sci Rep. 2015 Dec 18;5:18402
• All: 1 reference(s)