Auts2^tm1.1Mhos
Targeted Allele Detail

Summary

• Symbol: Auts2^tm1.1Mhos
• Name: autism susceptibility candidate 2; targeted mutation 1.1, Mikio Hoshino
• MGI ID: MGI:6156949
• Synonyms: Auts2^flox
• Gene: Auts2 Location: Chr5:131466171-132572059 bp, - strand Genetic Position: Chr5, 70.66 cM, cytoband G1
• Alliance: Auts2^tm1.1Mhos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243531
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 8 and a loxP site and a FRT-flanked neomycin cassette were inserted downstream of exon 8 in opposite orientation. Flp-mediated recombination removed the selection cassette leaving exon 8 floxed. (J:243531)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Auts2 Mutation: 64 strains or lines available

References

• Original: J:243531 Hori K, et al., Cytoskeletal regulation by AUTS2 in neuronal migration and neuritogenesis. Cell Rep. 2014 Dec 24;9(6):2166-79
• All: 3 reference(s)