Ogg1^m1
Spontaneous Allele Detail

Summary

• Symbol: Ogg1^m1
• Name: 8-oxoguanine DNA-glycosylase 1; mutation 1
• MGI ID: MGI:6157073
• Synonyms: OGG1-R336H
• Gene: Ogg1 Location: Chr6:113303959-113311149 bp, + strand Genetic Position: Chr6, 52.75 cM, cytoband E-F1
• Alliance: Ogg1^m1 page

Mutation origin

• Strain of Origin: various

Mutation description

• Allele Type: Spontaneous (Not Applicable)
• Mutation: Single point mutation
• Mutation details: A G-to-A change at the fifty-ninth nucleotide in exon 7 resulted in a substitution of arginine with histidine at position 336 (p.R336H) in a putative nuclear localization signal. The mutation led to disruption of the nuclear localization of the enzyme, although the activity remained normal. (J:59724)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Ogg1 Mutation: 23 strains or lines available

References

• Original: J:59724 Choi JY, et al., Thermolabile 8-hydroxyguanine DNA glycosylase with low activity in senescence-accelerated mice due to a single-base mutation. Free Radic Biol Med. 1999 Oct;27(7-8):848-54
• All: 2 reference(s)