Ogg1^m2
Spontaneous Allele Detail

Summary

• Symbol: Ogg1^m2
• Name: 8-oxoguanine DNA-glycosylase 1; mutation 2
• MGI ID: MGI:6157074
• Synonyms: OGG1-R304W
• Gene: Ogg1 Location: Chr6:113303959-113311149 bp, + strand Genetic Position: Chr6, 52.75 cM, cytoband E-F1
• Alliance: Ogg1^m2 page

Mutation origin

• Strain of Origin: various

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Single point mutation
• Mutation details: A C-to-T change at the twelfth nucleotide in exon 6 results in a substitution of arginine with tryptophan at postion 304 (p.R304W). (J:59724)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ogg1 Mutation: 23 strains or lines available

References

• Original: J:59724 Choi JY, et al., Thermolabile 8-hydroxyguanine DNA glycosylase with low activity in senescence-accelerated mice due to a single-base mutation. Free Radic Biol Med. 1999 Oct;27(7-8):848-54
• All: 2 reference(s)