Cd5^b
Spontaneous Allele Detail

Summary

• Symbol: Cd5^b
• Name: CD5 antigen; b variant
• MGI ID: MGI:6157523
• Synonyms: CD5.2, Ly-1.2
• Gene: Cd5 Location: Chr19:10695471-10716390 bp, - strand Genetic Position: Chr19, 7.16 cM
• Alliance: Cd5^b page

Mutation origin

• Strain of Origin: multiple strains

Mutation description

• Allele Type: Spontaneous (Not Applicable)
• Mutation: Undefined
• Mutation details: This variant is found in many inbred strains including C57BL/6J, C58/J, AKR/J, SJL/J, SWR. Sequence analysis shows that relative to the a variant of C3H/HeJ the b variant has point mutations that result in isoleucine instead of valine at amino acid 9, glutamine instead of leucine at amino acid 52, and phenylalanine instead of isoleucine at amino acid 71, all within the amino terminal scavenger receptor cysteine-rich D1 domain, in addition to 7 silent point mutations. (J:8546, J:40410)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Cd5 Mutation: 36 strains or lines available

References

• Original: J:5073 Boyse EA, et al., Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse. Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(19):175-93
• All: 21 reference(s)