9630013A20Rik^em1Qrlu
Endonuclease-mediated Allele Detail

Summary

• Symbol: 9630013A20Rik^em1Qrlu
• Name: RIKEN cDNA 9630013A20 gene; endonuclease-mediated mutation 1, Q Richard Lu
• MGI ID: MGI:6158415
• Synonyms: lncOL1-KO
• Gene: 9630013A20Rik Location: Chr14:84696164-84713864 bp, - strand Genetic Position: Chr14, 43.54 cM
• Alliance: 9630013A20Rik^em1Qrlu page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A genomic segment of 5.7 kb, containing the first four exons, was deleted using the CRISPR/Cas9 technology with two pairs of sgRNAs. qRT-PCR on brain tissue confirmed the lack of transcripts containing the deleted exons and a 75% decrease in transcription of the downstream exons. (J:256017)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any 9630013A20Rik Mutation: 0 strains or lines available

References

• Original: J:256017 He D, et al., lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS. Neuron. 2017 Jan 18;93(2):362-378
• All: 1 reference(s)